Finally, while the GO molecular function terms are consistently dominated by binding terms, we can notice how the larger models are capable of detecting more specific terms such as BHLH TF binding and E-box binding, which are subgroups of the more TF binding term that are known for the regulation of well known cancer-related genes such as NOTCH1 and MYC [61, 62] (Additional File 1: Figure S9). This evidence concerns the gene NOTCH1 and cancer.