GLI1 and cancer: Notably, the pathways missed in the smaller networks include apoptosis regulation (a hallmark of cancer [56]) and TP53 regulation of caspases (relevant to apoptosis control in tumors [57]), while terms for the estrogen-related signaling and GLI/Hedgehog signaling (whose role in cancer is well documented [58, 59]) would have been missed or underestimated by the smaller models.