NFkB signaling is also amplified in both lymphomas [12] as the most frequently mutated proteins in this pathway, in PMBL [13] and in cHL [7, 14, 15], are TNFAIP3 (tumor necrosis factor, a-induced protein 3), NFKBIE (NFKB inhibitor ɛ), NFKB2 (NFKB subunit 2) and IKBKB (inhibitor of NFKB kinase subunit β). Here, NFKB1 is linked to lymphoma.