With tumor cell stimulation, the CART-19 cells exhibited heightened functional cytokine and chemokine secretion, especially the production of GM-CSF, IFN-γ, IL-2, IL-4, IL-8, IL-12, IL-13, MIP-1α/β, and TNF-α/β (Fig. 1H). This evidence concerns the gene CSF2 and neoplasm.