The serum IgE concentration was greater in the eosinophil-dominant CRSwNP and plasma cell-dominant CRSwNP patients than in the control group (p < 0.0001); moreover, there was a significantly greater serum IgE concentration in the plasma cell-dominant CRSwNP group than in the eosinophil-dominant CRSwNP group (p < 0.0019). This evidence concerns the gene IGHE and chronic rhinosinusitis with nasal polyps.