Ultimately, tumor size (OR = 1.67, 95% CI: 1.14–2.43, P = 0.008), tumor number (OR = 1.86, 95% CI: 1.19–2.93, P = 0.007), AFP (OR = 1.68, 95% CI: 1.14–2.47, P = 0.009), portal hypertension (OR = 1.36, 95% CI: 0.91–2.05, P = 0.136), and GPR (OR = 1.80, 95% CI: 1.24–2.60, P = 0.002) were included in the predictive model for PFS. The gene discussed is AFP; the disease is portal hypertension.