The results of the present study concerning the association between TFF3, VEGF, and CT parameters demonstrate BV, BF and PS correlate positively with serum TFF3 and VEGF, but TTP correlate inversely with serum TFF3 and VEGF, it is suggested that the levels of serum TTF3 and VEGF are related to the microvascular function in colorectal cancer, and the parameters quantitative analysis were conducted using DSCT perfusion imaging have relevant trends, it suggests that TFF3 and VEGF have potential for clinical non-invasive evaluation of tumor angiogenesis in colorectal cancer. The gene discussed is TFF3; the disease is colorectal cancer.