Markedly decreased cell apoptosis and increased proliferation were found in the aortic SMCs of Myh11−/− mice [20], and the case with arterial stenosis in the intracranial vessel involvement caused by variants of MYH11 has been reported recently [21], indicating that there are other potential mechanisms of variants in MYH11 which remain to be explored. The gene discussed is MYH11; the disease is Arterial stenosis.