Therefore, we further detected the changes in glucose uptake and lactic acid content in HCC cells after the knockdown of β-catenin or the addition of inhibitors after overexpression of UCHL5. The results showed that overexpression of UCHL5 could promote glucose uptake and lactic acid production in cells, that is, promote glycolysis in cells (Fig. 5E, F). This evidence concerns the gene UCHL5 and hepatocellular carcinoma.