UCHL5 and hepatocellular carcinoma: Unfortunately, we have not evaluated whether the metabolite lactic acid is discharged into the microenvironment and whether it reshapes the microenvironment through lactic acid, leading to cell metastasis, which requires us to further explore the detailed mechanism of UCHL5. Meanwhile, given the relatively high incidence of HCC, the clinical samples we collected were limited, and we need to further expand the sample size for more in-depth mechanistic and clinical studies.