Previous studies have shown that the main pathological features of AP in AQP4-IgG seropositive NMOSD patients are inflammation and demyelination rather than necrosis [16, 17], this may explain the complete recovery of refractory hiccup, vomiting and nausea after treatment and the reversibility of the lesion in APS patients. The gene discussed is AQP4; the disease is autoimmune polyendocrinopathy.