Our results showed that, whether in the samples of cancer, adenoma or paracancer, the top three MP-RNA counted by partner numbers were coding for ASIC2, GPD1L and FAM213A, indicating that these three RNAs were always active in both normal and abnormal colon tissues (Supplementary Tables 4 and Supplementary data file 4). The gene discussed is PRXL2A; the disease is adenoma.