Tier 2 proteins included TNFRSF6B, and IL1RL2 for AA; ERBB3, IL6R, MMP12, ICAM1 and IL1RL2 for AD, and ICAM1, IL1RL2, MANF, STAT6 and TNFSF8 for AR. This evidence concerns the gene TNFSF8 and Alzheimer disease.