Examples of Tier 1 and 2 protein targets that are promising drug target candidates were STAT6, TNFRSF6B, IL1RL2, and IL6R for AA; CRAT, TNFRSF6B, ERBB3, IL6R, MMP12, ICAM1 and IL1RL2 for AD, and ICAM1, IL1RL2, MANF, STAT6 and TNFSF8 for AR. The gene discussed is TNFSF8; the disease is Alzheimer disease.