Similarly, interactions were found for ERBB3, IL6R, and MMP12 in the AD-specific PPI network (S. Figure 9) and for ERBB3, ICAM1, IL1RL2, MANF, STAT6 and TNFSF8 in the AR-specific PPI network (S. Figure 10). The gene discussed is TNFSF8; the disease is Alzheimer disease.