In our prior investigation into the therapeutic potential of micro ribonucleic acid-29a (miR-29a) antagonists for treating OI in a murine animal model, we demonstrated the ability of pre-miR-29a to augment the local expression of DKK1 in OI-afflicted mice, which was subsequently restored to normal levels by anti-sense miR-29a (Ko et al. 2023a). Here, DKK1 is linked to osteogenesis imperfecta.