Conversely, the expression level of RANKL was significantly lower in bone tissues from OI mice treated with DKK1-AS as opposed to bone tissues from untreated OI mice and from OI mice treated with DKK1-S (p < 0.001 for both OPG and RANKL) (Fig. 12). The gene discussed is TNFSF11; the disease is osteogenesis imperfecta.