A study on the mechanism of CAT in cerebral ischemia stated that CAT protected vascular structure and promoted angiogenesis in focal cerebral ischemic rats by activating the hypoxia-inducible factor 1-alpha (HIF-1α)/vascular endothelial growth factor (VEGF) pathway (Wang et al. 2020). This evidence concerns the gene HIF1A and Cerebral ischemia.