To delve into whether CAT assume a role in the process of cerebral ischemia through METTL3 mediated Beclin-1 m6A modification, RN-c cells received transfection with sh-METTL3 and sh-Beclin-1 and then OGD/R treatment, accompanied by CAT treatment during OGD/R. This evidence concerns the gene BECN1 and Cerebral ischemia.