TP53 and neoplasm: Not surprisingly, we observe the first evidence of functional p53 orthologs: nvp63, nvpEC53, and nvpVS53 in Nematostella vectensis (Pankow and Bamberger, 2007), a Cnidarian, the species in which evidence of tumor formation is first observed (Domazet-Lošo et al, 2014).