Tumors may grow constitutively in part because: (a) their “differentiated” cells have either lower injury thresholds to induce return to the cell cycle (loss of p53 lowers that threshold in non-neoplastic cells, as noted above); and/or (b) tumor cells constitutively consider their environment to be inflammatory; (c) and/or the tumors themselves create and maintain basal high-inflammatory microenvironments. This evidence concerns the gene TP53 and neoplasm.