FAAH and opiate dependence: Given that stress and poor social support are key risk factors for SUD relapse [9, 72], and current OST medications act all on the opioid system, our findings might suggest that pharmacologically targeting the ECS, especially elevating AEA levels by FAAH inhibitors, may be a novel treatment option of OUD that could result in reduced stress-induced craving, promoting abstinence and preventing OUD relapse without maintaining opioid dependence.