WEE1 and cancer: Within the ensemble of human protein kinases (referred as the human kinome) comprising 538 proteins in total, about 11% (58 kinases) are atypical members called dead kinases or pseudokinases as initially named by Manning et al., which represent a subgroup lacking catalytic activity and phospho-transfer to substrates, and of growing interest in cancer biology and treatment (Fig. 1) [1].