Somatic frameshift mutation MYO10 c.4554_4638del (N1519Ffs*5) and missense mutation c.4682G>T (G1561V) were identified in a GBM tumor in Family H. The frameshift c.4554_4638del (N1519Ffs*5) is located between a PH2 and a C-terminal MyTH4/FERM domain, and c.4682G>T (G1561V) is situated on the MyTH4 domain. Here, MYO10 is linked to neoplasm.