TP53 and brain neoplasm: Rare TP53 variants—c.993+12T>C, c.376-86T>C, and c.108G>A (Pro36 =) (Finnish population frequency 0.003–0.004), which are in linkage disequilibrium (LD) with each other (D ́ = 1.0, r2 = 1)—were detected in the affected individual in Family O (Supplementary Table 5, but the variants were not inherited from the family with history of brain tumors.