CD8A and neoplasm: Moreover, using multiplex ion beam imaging (MIBI) of paired tumor biopsy samples, we have observed modifications in the TME that correlated with VT1021 treatment including increased ratio of CD8+ T cells (cytotoxic T lymphocytes, CTL) to T Regulatory (Treg) cells, increased CD8+ Tumor-infiltrating lymphocytes (TIL), decreased T cell exhaustion, increased M1:M2 macrophage ratio and decreased microvascular density.