Of note, we found that cell-associated TSP-1 levels in PBMCs (0.80 μg/ml) and platelets (5.61 μg/ml) in healthy donors were significantly higher than baseline TSP-1 levels in PBMCs (0.29, 0.47 μg/ml) and platelets (1.18, 0.83 μg/ml) in evaluable patients with GBM and pancreatic cancer (Table 3). This evidence concerns the gene THBS1 and familial pancreatic carcinoma.