The RNA-Seq data revealed enrichment of genes linked to Ca2+ and Mg2+signaling in the tumor samples (Fig. 6A,B). The conversion of UMP to uracil is a bidirectional reaction (RHEA database ID: 13,020) regulated by Mg2+/Ca2+ and uracil phosphoribosyltransferase (UPRT) 24. Here, UPRT is linked to neoplasm.