Recent research has shown that adenosine turnover in the TME depends on the activity of ectonucleoside triphosphate diphosphohydrolase1(CD39)/5'-nucleotidase ecto (CD73) in oral squamous cell carcinoma 12.We have also observed high levels of purine metabolism in oral cancer 13. The gene discussed is ENTPD1; the disease is lip and oral cavity carcinoma.