Compared to the MM cell culture alone, cells co-cultured with Tregs exhibited a significant downregulation of class I MHC complex members (HLA-A, HLA-B, HLA-C, MICA and MICB), while the expression level of immunosuppressive factor PDL1 was upregulated in the MM cells with Treg co-culture (Fig. 2A,B). This evidence concerns the gene HLA-A and Miyoshi myopathy.