MAPT and frontotemporal dementia: This specificity of binding to tau fibrils over BSA, as previously discussed in Soloperto et al.22.Moreover, our data indicate a successful and efficient uptake of BT1-loaded NPM-HumAfFt by human iPSC-derived retinal cells42,43,53 This was demonstrated using two isogenic human iPSC lines, including a tau-mutant line harboring a MAPT mutation associated with FTD, providing a model to assess the efficacy of detecting pathological tau forms52.