CAMK2G and Atrophy: As excitotoxicity induced by chronic stress or abnormally high levels of extracellular glutamate is reported to cause dendritic atrophy and spinal loss, leading to neuronal dysfunction29–31, we used sparingly labeled layer II/III pyramidal neurons in the mPFC of Astrocyte cKO and Ctrl mice with a viral cocktail (1:1) of AAV-CaMKII-FLP and AAV-nEf1-FDIO-EYFP to evaluate neuronal morphological alterations in response to chronic stress.