In one study, global m6A methylation is decreased in the whole blood of both human and mice after acute stress, and in another study, ALKBH5 and FTO as m6A demethylases and METTL3, METTL14, and WTAP as m6A methyltransferases are altered in the MDD patients and the depression models. Here, METTL3 is linked to major depressive disorder.