Curiously, although Bregs populations have been implicated in pro-tumoral action in pancreatic adenocarcinoma80, and lymphoma81, in the current study we were not able to detect B10 Breg (CD5 + CD1d +) phenotype in the TME of neither the used murine models, suggesting that other mechanisms may be involved in the emergence of this phenotype other than differences in the breast tumor subtype. Here, CD1D is linked to breast neoplasm.