In agreement with these results, we reported a significant elevation in total B cells, as well as B LAG-3 + cells and plasma cells in the tDLNs not only 7 days after the initial tumor injection, but a sustained proliferation throughout the weeks, indicating a continuous influx of TAAs to tDLNs, leading to activation, proliferation and differentiation of B cells, that may or may not migrate to the TME. The gene discussed is LAG3; the disease is neoplasm.