Comparing the tumor progression of AP2ε-/-/Tg(GRM1) and Tg(GRM1)-mice we observed significant induction of local tumor progression for the tail (Fig. 3F, G first panel), perianal region (Fig. 3G, second panel), and ear (Fig. 3G, third panel) in the AP2ε deficient mice. This evidence concerns the gene TFAP2E and neoplasm.