ChIP Enrichment Analysis (ChEA) predicted upstream transcription factors of TFAP2Ε expression are amongst other transcription factors, such as JARID1B/KDM5B, Nanog, Sox10 and Sox2, associated with induction of stemness in melanoma (https://maayanlab.cloud/archs4/gene/TFAP2E#tissueexpression) [56, 57]. Here, SOX2 is linked to melanoma.