In addition, NETs activate trypsinogen mainly through the signal transducer and activator of transcription 3 (STAT3) and matrix metalloproteinase-9 (MMP-9) pathways, increasing the severity of the inflammatory response and reducing the accumulation of neutrophils, which can reduce the severity of AP to a certain extent [69, 70]. The gene discussed is STAT3; the disease is alkaline phosphatase measurement.