TP53 and neoplasm: While four primary tumor regions showed concordant TP53, IL6ST, and TPR mutations, only two primary tumor regions (P1 and P2, both EPE) also harbored an LRP1B mutation and high-level CNAs (e.g., like 16q loss and 8p12 loss) that were also present in the two LN (LN1 and LN2) metastasis foci.