The 8 loci found in both the LA GWAS and the AF GWAS are nearest to FAF1/C1orf85, CASQ2, TTN, PITX2, MYH6/MYH7, IGF1R, GOSR2, and MYO18B. At all 8 loci, the effect of each SNP on AF risk was in opposition to its effect on LAEF, and in most cases the effect of each SNP on AF was concordant with its effect on LAmin (Fig. 5). The gene discussed is TTN; the disease is atrial fibrillation.