HAVCR2 and neoplasm: TIM-3 on tumor-infiltrating DCs sequesters nucleic acid-carrying protein HMGB167 and thus can silence the immunogenicity of nucleic acids, resulting in reduced downstream cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) activation with reduced interferon-I, CXCR3, and CXCL9 production.68,69 In the CD8+ DC subset, TIM-3 recognizes phosphatidylserine and mediates phagocytosis of dying cell-associated antigens, which might silence tumor antigenicity70 (Fig. 2).