KDM1A and neoplasm: LSD1 inhibitors are widely applied in myeloid hematological malignancies as they promote the differentiation of myeloid cells via regulation of myeloid transcription factors GFI1 and PU.1.497,498 Regarding anti-tumor immunity, LSD1 undermines T cell-mediated cytotoxicity via promoting terminal differentiation of T cells499,500 (Fig. 4).