T cell responses are regulated by this axis indirectly via myeloid cells136 and directly through the CD47 and SIRPα expression on T cells.136,169,170 CD47 expressed on CD8+ T cells promotes their adhesion to cancer cells and sensitizes melanoma to ICIs when binding to SIRPα on cancer cells,171 and it also shields CD8+ T cells from necroptosis when interacting with conventional DCs, promoting the survival and functions of CD8+ T cells.172 These contrasting roles of the CD47-SIRPα axis in anti-tumor immunity need further study. The gene discussed is SIRPA; the disease is cancer.