In a murine model harboring the hotspot IKZF3 missense mutation in CLL, it was observed that the mutant AIOLOS triggered the activation of the BCR and nuclear factor-κB (NF-κΒ) signaling pathways, mirroring the effects of IKZF3 overexpression in primary CLL cells [34]. The gene discussed is IKZF3; the disease is B-cell chronic lymphocytic leukemia.