From an immunological point of view, severe COVID-19 and poor prognosis associate with a specific profile showing an exaggerated immune response, characterized by a “cytokine storm”, with high levels of IL-6 and IL-10 among others, and by a dramatic changes in blood cell sub-populations, with decreased lymphocytes, T-cell subsets, eosinophils, and platelets, and increased neutrophils and neutrophils-to-lymphocytes ratio (Chen et al. 2020; Carissimo et al. 2020; Martín-Sánchez et al. 2021; Hadjadj et al. 2020; Mann, et al. 2020; Laing et al. 2020; Ahern et al. 2022). This evidence concerns the gene IL6 and COVID-19.