Of note, CD177 was also common when studying the overlap between our early signature and differentially expressed genes associated with the evolution towards severe Influenza infection (Fig. 3d; Supplementary Table S10), another virus infection, underlining the importance neutrophil induction beyond interferon activation in virus infections (Zerbib et al. 2020; Dunning et al. 2018). Here, CD177 is linked to viral infectious disease.