A comparative analysis of Aβ pathology across APOE genotypes was performed in the frontal cortex of 21 advanced sporadic AD cases, after an anti-Aβ 4G8 immunohistochemistry (n = 11 APOEε3/ε3 and n = 10 APOEε4/ε4 cases, Fig. 6a–b). The gene discussed is APOE; the disease is Alzheimer disease.