SRSF1 and Alzheimer disease: These new results extend our previous analysis by bringing to light additional RNA-associated proteins of interest, which were previously detected as present in the neurofibrillary tangle proteome, although they were below the threshold to be considered as pTau interactors so far [26]: the splicing factors SRSF1 (also known as SF2/ASF) and TRA2B, involved in the regulation of the alternative splicing of Tau exon 10 impacting the ratio of Tau isoforms with three or four microtubule binding repeats domains (3R or 4R, with a 4R:3R ratio shifted from approximately 1:1 to 2:1 in AD) [17, 20, 33].