Distinct cell clusters of EGFR-high and CCNE1-high cells were found predominantly in the EpCAM+ clusters in TNBC (Fig. 2B), where EGFR was expressed in 23.1% ± 1.6% of EpCAM+ cells, compared with 4.4% ± 0.7% in HER2+ and 3.5% ± 0.5% in ER+ tumor cells. Here, ESR1 is linked to neoplasm.