MRC1 and Familial prostate cancer: In prostate cancer, TAMs characterised by an immunosuppressive M2 phenotype represent a major component of the tumour microenvironment (TME).66, 67, 68, 69 As prostate tumours are infiltrated with CD206 positive M2 macrophages and this correlates with progression to metastatic disease,70 we assessed the effects of ST6GAL1 overexpressing prostate cancer cells on human macrophages using a co-culture study.