ST6GAL1 and neoplasm: More importantly, when compared to mice bearing control tumours, mice bearing ST6GAL1 overexpressing tumours had a 4.02-fold increase in the number of osteoclasts (unpaired t test, p = 0.0055) (Fig. 4d) and a 55% reduction in the number of osteoblasts on endocortical surfaces in tibias without overt tumours (unpaired t test, p = 0.0452) (Fig. 4e).