Effective treatment ofmetastatic cancers usually requires theuse of chemotherapy, but anticancer therapy has low selectivity andserious side effects.1−10 Moreover, multiple drugs are used, due to frequent resistance tosingle agents, and the overexpression of multidrug resistance (MDR)transporters such as P-glycoprotein (Pgp), which efflux drugs fromthe cells, thus keeping their concentrations below a cell-killingthreshold.11,12 The search for more efficient,safer anticancer agents unaffected by MDR is warranted. The gene discussed is PGP; the disease is cancer.