Therefore, to evaluate how the loss of O-mannosylated DG in cardiac muscle affects the development and progression of cardiomyopathy, we generated mice in which the Pomt1 gene was deleted specifically in striated muscle (Pomt1 cKO; SI Appendix, Fig. S2 A and B and Fig. 2A). The gene discussed is POMT1; the disease is cardiomyopathy.