Also, G/G genotype (cOR = 5.83; 95% CI, 1.19–28.4, p = 0.029) of MMP2 rs243864 and T/T genotype (cOR = 1.79; 95% CI, 1.16–2.76, p = 0.008) of MMP12 rs652438 independently contributes to the susceptibility of COPD. This evidence concerns the gene MMP12 and chronic obstructive pulmonary disease.