For SNP-SNP interaction, the positive interaction between rs243864 G/G genotype of MMP2 and rs652438 T/T genotype of MMP12 was found, and the combination of risk genotypes has a high risk of COPD (OR = 12.92; 95% CI, 1.46–114.4, p = 0.021). The gene discussed is MMP12; the disease is chronic obstructive pulmonary disease.