HLA-DRB1 and myeloid sarcoma: Shams et al. recently showed an association between the MS PRS and thalamic atrophy, while Yates et al. found that the HLA-DRB1*1501 risk allele correlated with neuropathology on autopsy, both indicating that genetic factors involved in disease onset also relate to end-organ injury [53, 63, 64].