Many of the loci identified have strong associations with cardiovascular disease risk factors such as FTO (fat mass and obesity-associated; associated with BMI), PITX2 (the PITX2 transcription factor; associated with atrial fibrillation [AF]), and LPA (lipoprotein(a); associated with coronary artery disease [CAD]). The gene discussed is PITX2; the disease is obesity due to melanocortin 4 receptor deficiency.