A particular common missense variant within BAG3, characterized by the substitution of cysteine with arginine at position 151 of the BAG3 protein (C151R; rs2234962) [104], demonstrates a potential cardioprotective function in GWAS of DCM, HF, and ejection fraction [108] with risk for HCM [52]. The gene discussed is BAG3; the disease is familial dilated cardiomyopathy.