In almost all murine tumor models, CD8+ T cells are essential since depleting CD8+ T cells markedly reduces the anti-tumor effects of IR (Burnette et al., 2011; Deng et al., 2014a; Lee et al., 2009; Liang et al., 2013b; Weichselbaum et al., 2017). Here, CD8A is linked to neoplasm.