This is consistent with other diseases in which MR activation on its own is benign; however, introduction of a second hit such as inflammation, infarction, oxidative stress or a high salt diet leads to cardiomyopathy (Brilla and Weber, 1992; Sun et al., 2002; di Zhang et al., 2008; He et al., 2011; Ruhs et al., 2012; Fraccarollo et al., 2011). Here, NR3C2 is linked to cardiomyopathy.