Interestingly, prednisone possesses both of these properties; chronic treatment with pharmacological glucocorticoids can cause downregulation of the GR at the mRNA and protein level (Silva et al., 1994; Shimojo et al., 1995; Andreae et al., 2001) as well as downregulation of physiological GR ligands through adrenal suppression as seen in patients with DMD (Hathout et al., 2016). This evidence concerns the gene NR3C1 and Duchenne muscular dystrophy.