In a murine model of pancreatic cancer, gemcitabine upregulated secretion of several cytokines, including interferon gamma (IFNγ) and tumor necrosis factor alpha (TNFα),24 both of which are known transcriptional inducers of MHC‐I and PD‐L1.144, 146. The gene discussed is CD274; the disease is familial pancreatic carcinoma.