These risk factors include smoking, advanced pathology stage (Stage II−IV), lower historical differential grade, solid historical subtype, age ≥ 50 years old, tumor size ≥2 cm, ki67 expression proportion ≥ 10%, family history of cancers, BMI ≥24, lymph node metastasis, as well as the presence of STAS and vascular invasion. The gene discussed is MKI67; the disease is metastatic malignant neoplasm in the lymph nodes.