HFD mice develops steatosis via JNK1 activationMCD mice develops non-alcoholic steatohepatitis via JNK1 activationJNK1 knockdown mice using antisense oligonucleotide leads to decreased steatohepatitis and insulin resistance even when being fed HFDJNK1 induces liver injury in MCD miceJNK1/2 deficiency in bone marrow transplantation mice model develops liver fibrosis by inducing chronic inflammation via the action of JNK1knockdown of JNK2 display steatohepatitis, which has similar phenotype as wild type miceAblation of JNK2 resulted in increased liver injury through increased apoptosis. The gene discussed is MAPK9; the disease is Insulin resistance.