MAPK8 and metabolic dysfunction-associated steatohepatitis: JNK1 has been found to be a contributor towards steatosis development in mice fed with a HFD.[125] In another study, which used methionine- and choline-deficient (MCD) diets in mice to model non-alcoholic steatohepatitis, JNK1 was shown to be responsible for the development of NASH.[145] JNK1 knockdown using antisense oligonucleotide leads to decreased steatohepatitis and insulin resistance even when fed a HFD.