Overexpression of p38α/β dominant negative mice display cardiac hypertrophy response, which is also displayed by wild type mice.Overexpression of dominant negative MKK3 and MKK6 in mice develop cardiac hypertrophyOverexpression of p38 in mice do not result in cardiac hypertrophy.Long term inhibition of p38 using RWJ67657 resulted in attenuation of cardiac remodellingTreatment of p38 inhibitor SB203580 and FR167653 also display reduced cardiac remodellingPro-inflammatory cytokines production in myocytes via the p38 pathway for the induction of fibrosis and hypertrophy. The gene discussed is MAPK1; the disease is cardiac hypertrophy.