NLRP3 and ischemic stroke: As such, modulation of MKP-1 levels following an ischaemic stroke may provide a potential approach in reducing ischaemic injury to the brain.[122] As discussed above, inhibition of p38 signalling pathway resulted in a decrease in the expression of NLRP1 and NLRP3 inflammasomes, which in turn reduces the expression of inflammatory precursors and proteins such as IL-1β and IL-18 during ischaemic conditions.