This results in hepatic insulin resistance and diabetes, with further metabolic related pathological correlates to hepatic steatosis and non-alcoholic fatty liver disease (NAFLD).[133] However, in another study, when 3T3-L1 adipocytes are isolated from type II diabetic patients, it was observed that there is an increased level of MAPKs signalling as well as p38 activation. Here, MAPK1 is linked to diabetes mellitus.