MKP-1 in ERK axis may be a driver/negative regulator of adipogenesis and development of obesity, depending on temporal regulationMKP-3 may be a driver of adipogenesis and development of obesityJIP1 may be a driver of adipogenesis and development of obesity through its interaction with JNK. The gene discussed is MAPK8; the disease is obesity due to melanocortin 4 receptor deficiency.