In the area of stroke pathogenesis, our study has previously established that inhibition of p38 signalling pathway in neuronal cells subjected to ischaemic conditions also resulted in a decrease in the expression of NLRP1 and NLRP3 inflammasomes, which in turn reduces the expression of inflammatory precursors and proteins such as IL-1β and IL-18. The gene discussed is MAPK1; the disease is stroke disorder.