Grb2 knockout mice show resistance to cardiac hypertrophyOverexpression of MKP-3 in mice display cardiac hypertrophy through reduction in ERK1/2 activationTreatment of all trans retinoic acid to aortic banded rats upregulates MKP-1/2 and downregulates JNK pathway, thereby prevent the development of cardiac remodellingMKP-1 knockout mice results in limited cardiac hypertrophic responseMKP-1/2 double knockout mice display immense hypertrophic responses. The gene discussed is MAPK8; the disease is cardiac hypertrophy.