Honarvar et al. (88) in an 8-week randomized double-blind, placebo-controlled trial with 80 individuals experiencing episodic migraines, discovered that the combination of omega-3 PUFAs and nano-curcumin significantly reduced migraine attack frequency and serum levels of IL-1β in a synergistic manner, though the initial significant reduction in IL-1β gene expression did not remain significant after Bonferroni corrections. The gene discussed is IL1B; the disease is migraine disorder.