IL4 and migraine disorder: Djalali et al. (86) conducted a randomized, double-blind, placebo-controlled trial over 8 weeks with 40 patients prone to episodic migraines, finding that omega-3 PUFAs supplementation increased anti-inflammatory cytokine IL-4 and decreased pro-inflammatory cytokine IFN-γ levels, suggesting a potential beneficial effect on inflammatory responses in migraine patients.