Hence, targeting, and inhibiting onco-EGFR will bring down cancers associated with various genes in the downstream pathway of EGFR, thereby, confirming the potential of the compound as an anticancer agent. A study by Hajrah et al. [26] demonstrated the effect of Ricinus extract on MCF7 cells leading to a downregulation of PIK3R3 oncogene DPP4 oncogene and the upregulation of PPAR-γ expression. This evidence concerns the gene PIK3R3 and cancer.