An increased level of M2 CCL22 (C–C motif chemokine 22), decreased level of M1 CXCL11(C-X-C motif chemokine 11), and decreased M1/M2 ratio (CXCL11/CCL22) have been observed in the macular choroidal trephines (MCT) of old compared to young non-AMD. Here, CCL22 is linked to age-related macular degeneration.