In AD, NLRP3 inflammasome signaling is triggered by multiple factors such as Aβ, tau, activated glial cells, impaired autophagy, and endoplasmic reticulum stress that ultimately leads to the release of pro-inflammatory cytokines such as IL-1β and IL-18 (Jha et al., 2023). The gene discussed is NLRP3; the disease is Alzheimer disease.