MAPT and Alzheimer disease: Significant progress has been made in diagnosis via FDA-approved PET-amyloid and -tau imaging, CSF Aβ, and more recently plasma phosphorylated tau 217 immunoassay (Ashton et al., 2024; Barthélemy et al., 2024) and disease-modifying treatments with anti-Aβ antibodies for AD, aimed at slowing down its progression (Dyck et al., 2022; Boxer and Sperling, 2023).