ALB and primary biliary cholangitis: In a previously published study by Nishimura et al., which discussed the synthesis and drug properties of PBC-IP, it was reported that PBC-IP was widely distributed in the cytoplasm.14 In our previous studies, cellular boron concentrations in PBC with folate receptor targeting and BC-IP with albumin ligands were not notably high.24,27,43 Although the precise mechanism underlying the cellular uptake of PBC-IP remains uncertain, it is conceivable that the concurrent presence of both albumin ligands and folate receptor targeting may influence their cellular distribution.