MicroRNAs isolated from TEPs also carry many cues of HCC-specific upregulations, such as enriched RhoA, SPINK1, and CTNNB1, along with a considerable upregulation of SERPIND1, IFITM3, and CD41+ levels, to demarcate HCC and cirrhosis patients (Waqar et al., 2021). This evidence concerns the gene SPINK1 and hepatocellular carcinoma.