AKT2 and colorectal carcinoma: Some genes found in CTCs play a role in the prognostic classification of CRC, including COX-2 (Cai et al., 2019), LGR-5 (Wang et al., 2018), and AKT-2, wherein positive AKT-2 expression may predict shorter median survival, PFS, and OS (Welinder et al., 2015) (Table 1).