Studies have revealed a significant decrease in the gap junction protein expression along with cytoplasmic membrane relocation during the progression of colorectal cancer [11,12], Cx43 in the samples of colon cancer was significantly lowered by 75% than that in the control group, with the characteristics of the tumor suppressor, and organization and tumor invasion was significantly associated with cancer [13]. This evidence concerns the gene GJA1 and malignant colon neoplasm.